Antioxidant constituents from the stems and fruits of Momordica Charantia

KW Lin; SC Yang; CN Lin

doi:10.1055/s-0032-1320814

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Planta Med 2012; 78 - PI127
DOI: 10.1055/s-0032-1320814

Antioxidant constituents from the stems and fruits of Momordica Charantia

KW Lin ¹, SC Yang ¹, CN Lin ²

¹School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
²Faculty of Fragrance and Cosmetics, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Congress Abstract

A new cucurbitane-type triterpene glycoside taiwacin A (1), a new pentanorcucurbitane, taiwacin B (2) and a known cucurbitane-type triterpene glycoside (3), and a known steroid glycoside (4), were isolated from the stems and fruits of Momordica charantia, respectively. These four compounds, 1, 2, 3 and 4 revealed ABTS radical cation scavenging activity with an IC₅₀ values of 119.1±4.3, 204.5±1.2, 159.7±11.0 and 98.1±2.4µM, respectively. Compounds 1 and 3 displayed an inhibitory effect on xanthine oxidase activity with IC₅₀ values of 24.1±3.4 and 158.3±35.6µM, respectively. Compounds 2-4 significantly displayed O₂ ^· ^-scavenging activity with an IC₅₀ values of 12.5±2.2, 16.5±0.1 and 27.3±1.4µM, respectively and the relative oxygen radical absorbance capacity values of 2 and 3, using ORAC-pyrogallol red (PGR) assay, were determined to be 0.88±0.02 and 0.55±0.09, respectively. These findings showed that 1-4 may be used as antioxidants.