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DOI: 10.1055/s-0032-1320797
Desmutagenic and antimutagenic potential of Khaya grandifoliola (C.DC.) Meliaceae
Five phenolics were isolated for the first time from the ethanol extract of Khaya grandifoliola leaves. These compounds were identified [1] using spectroscopic analysis (UV, 1H-NMR, 13C-NMR and ESI) as Quercetin 3-O-rhamnoglucoside (rutin), Quercetin 3-O-rhamnoside, Quercetin 3-O-glucoside, Quercetin aglycon and the new 6- methoxycoumarin, 7- arabinofuranoside. Desmutagenic and antimutagenic [2] activities of specimen extracts of immaculate khaya grandifoliola leaves and flowers were ascertained by measuring the inhibition of Salmonella typhimurium TA 100 His+ revertants induced by ethyl methane sulphonate EMS and ribose lysine RL. A frustration of the induced reversion was observed. The alcoholic extract of both leaves and flowers of khaya grandifoliola exhibited desmutagenic and antimutagenic activity against EMS and RL induced reversion.