Planta Med 2012; 78 - PI110
DOI: 10.1055/s-0032-1320797

Desmutagenic and antimutagenic potential of Khaya grandifoliola (C.DC.) Meliaceae

F Hashem 1, ES Aboutabl 2, S El-Souda 3, M Moharam 4, A Mammoun 1
  • 1Pharmacognosy depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt
  • 2Pharmacognosy depart, Faculty of Pharmacy, Cairo Univeristy, Kasr-El-Aini, Cairo, Egypt
  • 3Chemistry of natural compounds depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt
  • 4Microbiology depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt

Five phenolics were isolated for the first time from the ethanol extract of Khaya grandifoliola leaves. These compounds were identified [1] using spectroscopic analysis (UV, 1H-NMR, 13C-NMR and ESI) as Quercetin 3-O-rhamnoglucoside (rutin), Quercetin 3-O-rhamnoside, Quercetin 3-O-glucoside, Quercetin aglycon and the new 6- methoxycoumarin, 7- arabinofuranoside. Desmutagenic and antimutagenic [2] activities of specimen extracts of immaculate khaya grandifoliola leaves and flowers were ascertained by measuring the inhibition of Salmonella typhimurium TA 100 His+ revertants induced by ethyl methane sulphonate EMS and ribose lysine RL. A frustration of the induced reversion was observed. The alcoholic extract of both leaves and flowers of khaya grandifoliola exhibited desmutagenic and antimutagenic activity against EMS and RL induced reversion.

6- methoxy, coumarin-7-arabinofuranoside