Planta Med 2012; 78 - PI99
DOI: 10.1055/s-0032-1320786

Biocoversion of formestane by Beauveria bassiana ATCC 7159

J Narvaez 1, GDA Martin 1
  • 1Department of Chemistry, Biochemistry and Physics, The University of Tampa, 401 West Kennedy Boulevard, Tampa, FL 33606, USA

The bioconversion of 4-hydroxyandrost-4-ene-3,17-dione (formestane) 1 with Beauveria bassiana yielded the reduced 4,17β-dihydroxyandrost-4-en-3-one 2, 4α,17β-dihydroxyandrostan-3-one 3, and 4,11α,17β-trihydroxyandrost-4-en-3-one 4. All the metabolites showed significant cytotoxicity activities against the MCF-7 breast cancer cell lines. The bioactivities and structural elucidation of these metabolites by chemical and spectroscopic means are reported herein.