Metabolomic manipulation of marine fungi through epigenetic modification via histone deacetylase inhibition

D Demers; J Beau; T Mutka; D Kyle; BJ Baker

doi:10.1055/s-0032-1320781

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Planta Med 2012; 78 - PI94
DOI: 10.1055/s-0032-1320781

Metabolomic manipulation of marine fungi through epigenetic modification via histone deacetylase inhibition

D Demers ¹, J Beau ¹, T Mutka ², D Kyle ², BJ Baker ¹

¹Department of Chemistry and Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33620, USA
²Department of Global Health, University of South Florida, Tampa, FL 33620

Congress Abstract

Recent studies have shown marine fungi to be interesting targets of natural product investigation due to their ability to be grown under a variety of conditions that alter secondary metabolite production. Epigenetic modification via the histone deacetylase (HDAC) inhibitor sodium butyrate has been shown to increase production of metabolites of interest as well as previously unidentified compounds. In the spring of 2012, a collection of endophytic fungi was isolated from Florida mangroves. Crude extracts of these isolates were submitted for bioassay against infectious diseases including malaria and methicillin resistant Staphylococcus aureus (MRSA). This study illustrates examples in which modified versus unmodified extracts yielded both differing bioassay results and metabolomics profiles.