Planta Med 2012; 78 - PI93
DOI: 10.1055/s-0032-1320780

Active compounds against plasmodium falciparum isolated from Lentinus sp

J Guizado 1, T Hoffman 2, M Piepenbring 3, L Cubilla-Rios 1
  • 1Laboratorio de Bioorgánica Tropical, Universidad de Panamá, Panamá
  • 2Department of Biology, Universidad Autónoma de Chiriqui, Panamá
  • 3Department of Microbiology, J. W. Goethe-University Frakfurt am Main, Germany

One hundred and thirty two samples of macro and micro fungal strains have been collected as part of an inventory and to investigate their capability to produced active substances against tropical diseases, bacteria and plant pathogenic fungi. After their identification and literature analysis only 13 fungi were selected for further work; the fungal strain Lentinus sp. (LC46) was cultivated in PDA and MEA. Both extracts (AcOEt) showed a promising activity against P. falciparum (100% GI) and T. cruzi (82% GI) at 10µg/mL. Six compounds have been isolated from the extract obtained from the culture in MEA, the determination of their activity is under evaluation. Two of these compounds have been reported previously 1, 2 (Nat Prod Commun 2009, 4: 501–506.); we present here two tentative structure for the new compounds 3 and 4.

Acknowledgement: SENACYT grant Col 10–060