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DOI: 10.1055/s-0032-1320773
Two benzoquinones and one terphenyl compound from an unidentified fungus (MSX 47445)
Three bioactive compounds were isolated from an organic extract of an unidentified fungus (MSX 47445) using bioactivity-directed fractionation methodology as part of a search for anticancer leads from filamentous fungi. Of these, two were benzoquinones [betulinan A (1) and betulinan C (3)] and the third was a terphenyl compound BTH-II0204–207:A (2). The structures of the isolated compounds were elucidated using a set of spectroscopic and spectrometric techniques; the structure of the new compound (3) was confirmed via X-ray crystallography. Compounds (1-3) were evaluated for cytotoxicity against a human cancer cell panel, for antimicrobial activity against an array of bacteria and fungi, and for phosphodiesterase (PDE4B2) inhibitory activities. The putative binding mode of 1-3 with PDE4B2 was examined using a validated docking protocol, and the binding and enzyme inhibitory activities correlated.