Sterols of the white nose bat fungus

JL Giner; H Ceballos; TR Horton; JC Okoniewski

doi:10.1055/s-0032-1320767

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Planta Med 2012; 78 - PI80
DOI: 10.1055/s-0032-1320767

Sterols of the white nose bat fungus

JL Giner ¹, H Ceballos ¹, TR Horton ², JC Okoniewski ³

¹Department of Chemistry, SUNY-ESF, Syracuse, NY 13210
²Department of Biology, SUNY-ESF, Syracuse, NY 13210
³NYSDEC – Wildlife Pathology Unit, Delmar, NY 12054

Congress Abstract

In recent years, the white nose bat fungus, Geomyces destructans, has decimated the bat populations of North America. Because fungal sterols and their biosynthesis are the targets of most antifungal compounds used in medicine and agriculture, a thorough sterol analysis was carried out using RP-HPLC separation and 600MHz NMR analysis. The complete sterol analysis will be presented. While the major sterol was ergosterol, interestingly, an unknown species of Geomyces from a bat cave on Long Island contained a sterol with a side chain commonly found in marine dinoflagellates.