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Planta Med 2012; 78 - PI34
DOI: 10.1055/s-0032-1320721
DOI: 10.1055/s-0032-1320721
Diterpenes from the French marine alga Bifurcaria bifurcata (Sargassaceae) inhibit growth of the human pathogen P. Falciparum
Eleganolone has been isolated by a bioassay-guided approach from a crude ethyl acetate extract of Bifurcaria bifurcata, as a putative active principle responsible of the strong trypanocidal activity previously found in this extract. The in vitro activity of eleganolone against Trypanosoma brucei rhodesiense and Trypanosoma cruzi trypomastigotes will be presented together with its in vitro antiprotozoal activity against other protozoa. Cytotoxicity against mammalian cultured cells and selectivity indexes will also be presented.