Planta Med 2012; 78 - PI34
DOI: 10.1055/s-0032-1320721

Diterpenes from the French marine alga Bifurcaria bifurcata (Sargassaceae) inhibit growth of the human pathogen P. Falciparum

JB Galle 1, M Kaiser 2, AM Rusig 3, C Vonthron-Sénécheau 1
  • 1UMR CNRS 7200 Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, Université de Strasbourg, 64701 Illkirch, France
  • 2Swiss Tropical and Public Health Institute, University of Basel, 4002 Basel, Switzerland
  • 3CNRS INEE – FRE3484 Biologie des Mollusques Marins et des Ecosystèmes Associés, Université de Caen Basse-Normandie, 14032 Caen Cedex, France

Eleganolone has been isolated by a bioassay-guided approach from a crude ethyl acetate extract of Bifurcaria bifurcata, as a putative active principle responsible of the strong trypanocidal activity previously found in this extract. The in vitro activity of eleganolone against Trypanosoma brucei rhodesiense and Trypanosoma cruzi trypomastigotes will be presented together with its in vitro antiprotozoal activity against other protozoa. Cytotoxicity against mammalian cultured cells and selectivity indexes will also be presented.