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Planta Med 2012; 78 - PI26
DOI: 10.1055/s-0032-1320713
DOI: 10.1055/s-0032-1320713
Ammosamide d from a marine-derived Streptomyces variabilis
In our continuing efforts to search for natural products from marine bacteria with selective cytotoxicity against cancer cell lines, we obtained a series of fractions from the marine-derived Streptomyces variabilis (strain SNA-020) that exhibited modest selectivity and potency for the MiaPaca-2 pancreatic cancer cell line. Analysis of the active fractions by LC-UV-MS showed the presence of chlorine bearing molecules to ammosamide A and B, leading to the isolation of ammosamide D (1). It is the first example of an oxidized analog resulting in a 5,6-dioxo-5,6-dihydroquinoline ring system. Ammosamide D has modest cytotoxicity to the Mia-Paca2 pancreatic cancer cell line (IC50=3.2µM).