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Planta Med 2012; 78 - PI15
DOI: 10.1055/s-0032-1320702
DOI: 10.1055/s-0032-1320702
Bunodosines: novel analgesic acylamino acids from the venom of the sea anemone Bunodosoma cangicum
Sea anemones are known as a rich source of protein and peptide toxins. In contrast, however, only little is known about the non-peptidic, small molecules in the sea anemones. We have been searching for small molecule toxins in the venom of the Brazilian sea anemone, Bunodosoma cangicum, which has led to the isolation of new acylamino acids, bunodosine 391 (BDS 391, 1) and bunodosine 405 (BDS 405, 2), showing a potent analgesic activity mediated by serotonin receptors.