Planta Med 2012; 78 - PI14
DOI: 10.1055/s-0032-1320701

Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum

SA Ross 1, 2, RF Abou El-Ezz 3, SA Ahmed 4, MM Radwan 1, NA Ayoub 5, MS Afifi 3, 5, SI Khalifa 6
  • 1National Center for Natural Products Research
  • 2Department of Pharmacognosy, School of Pharmacy, University of University of Mississippi, University, MS 38677, USA
  • 3Department of Pharmacognosy, Faculty of Pharmacy, Misr International University, Cairo, Egypt
  • 4Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
  • 5Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
  • 6College of Pharmacy, Qatar University, Doha 02713, Qatar

A chemical investigation of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two new cembranoid diterpenes, (2, 6) and, one new natural cembranoid (3), as well as three known compounds, Sarcophine (1), (+)-7α,8β-dihydroxydeepoxy sarcophine (4) and Sarcophytolide (5). Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR and HRMS. The antimicrobial and cytotoxic activities of the isolates were evaluated.