Planta Med 2012; 78 - PI6
DOI: 10.1055/s-0032-1320693

Briarenolides E-J, new Briarane diterpenoids from an octocoral Briareum sp

YD Su 1, 2, PH Hong 2, 3 , YH Chen 2, JH Sheu 1, PJ Sung 1, 2, 3
  • 1Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
  • 2National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
  • 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

Six new briarane-type diterpenoids, briarenolides E-J (1-6), were isolated from an octocoral Briareum sp. The structures of briaranes 1-6 were established by spectroscopic methods and by comparison the spectral data with those of known briarane analogues. It is worth noting that briarenolide E (1) is the first 2-ketobriarane, briarenolide F (2) is the first 6-hydroperoxybriarane, and briarenolide I (5) is the first 6-oxymethylbriarane analogues. Briarenolide E (1) displayed modestly inhibitory effects on the generation of superoxide anion and the release of elastase and briarenolide F (2) displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.

1

2

3

4

5

6