Planta Med 2012; 78 - PI5
DOI: 10.1055/s-0032-1320692

New verticillane diterpenoids from Cespitularia taeniata

JY Chang 1, YC Lin 1, TL Hwang 2, YC Shen 1
  • 1School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan
  • 2Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1–3). Compound 1 possesses a rare nor-verticillane skeleton with two adjacent hydroxyl groups at C-5 and C-6, while seco-compound 2 with an aldehyde group at C-9 results from an unusual bond cleavage between C-9 and C-10. Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB.