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Planta Med 2012; 78 - PI5
DOI: 10.1055/s-0032-1320692
DOI: 10.1055/s-0032-1320692
New verticillane diterpenoids from Cespitularia taeniata
Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1–3). Compound 1 possesses a rare nor-verticillane skeleton with two adjacent hydroxyl groups at C-5 and C-6, while seco-compound 2 with an aldehyde group at C-9 results from an unusual bond cleavage between C-9 and C-10. Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB.