Planta Med 2012; 78 - PI3
DOI: 10.1055/s-0032-1320690

New spongians isolated from a species of Cacospongia SP

SM Parrish 1, WY Yoshida 1, M Kelly 2, P Williams 1
  • 1Department of Chemistry, University of Hawaii at Manoa, Honolulu Hawaii, 96822
  • 2National Centre for Aquatic Biodiversity and Biosecurity, National Institute of Water and Atmospheric Research, Ltd, 41 Market Place, Auckland Central 1010, New Zealand

Two norditerpenes (1–2) and one diterpene (3) were isolated from a tropical Suluwesi sponge in the genus Cacospongia sp. (Order Dictyoceratida, Family Thorectidae). Diterpene 3 contains a unique pyridine moiety as the D ring. The structures of 1–3 were deduced by analysis of the spectrometric and spectroscopic data. The structure elucidation of 3 was complicated by the rapid exchange of the axial proton at the C-11 position with deuterium from methanol.