Planta Med 2012; 78 - PH17
DOI: 10.1055/s-0032-1320676

Hypoglycemic effect of Bauhinia holophylla Steud. in streptozotocin diabetic mice

NAPC Henriques 1, LG Pieroni 1, AL Dokkedal 2, JR Bosqueiro 2
  • 1Institute of Bioscience, UNESP – São Paulo State University, p.c. 510, 18618–970 Botucatu, SP, Brazil
  • 2Faculty of Sciences, UNESP – São Paulo State University, p.c. 473, 17033–360 Bauru, SP, Brazil

B. holophylla is widely used in folk medicine. We investigate hypoglycemic properties of crude extract of B. holophylla in streptozotocin-diabetic mice. Male Swiss mice (90-days old, 40g) were divided in 4 groups: CTLSAL (normal mice treated with saline), CTLEXT (normal mice treated with B. holophylla, 15 days, 400mg/kg.day), STZSAL (diabetic mice treated with saline) and STZEXT (diabetic mice treated with B. holophylla, 15 days, 400mg/kg.day). STZEXT had decreased glucose and lipid levels, hydric and food ingestion and increased hepatic glycogen compared to STZSAL (P<0.05), indicating beneficial effects in the treatment of streptozotocin diabetic mice.