Blood alcohol concentrations after oral administration of Thyme herb and Primrose root fluid extract (T+P) to children

C Nauert; S Weykam

doi:10.1055/s-0032-1320663

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Planta Med 2012; 78 - PH4
DOI: 10.1055/s-0032-1320663

Blood alcohol concentrations after oral administration of Thyme herb and Primrose root fluid extract (T+P) to children

C Nauert ¹, S Weykam ¹

¹Medical Department Cassella-med GmbH, D-50670 Cologne

Congress Abstract

The aim of this open clinical study (indication: acute bronchitis) was to prove that after the oral administration of a single dose of T+P (containing 4.9% EtOH) the blood EtOH concentrations in children (1–4y n=12, 5–12y n=4) rest below a safety threshold of 0.125 ‰. T+P was administered over a period of 7–9 days (6×2.5ml or 4×7.5ml/d). During visit 2 (d 3–5) blood samples were taken 45 and 90min (only 5–12-y) after the second application and the EtOH concentrations were measured with a validated dehydrogenase assay. In addition the clinical symptoms (Bronchitis Severity Score, BSS) and the tolerability were assessed. All measured blood EtOH concentrations stayed far below the safety threshold of 0.125‰ and BSS decreased significantly: