Planta Med 2012; 78 - PG9
DOI: 10.1055/s-0032-1320652

Innate defense response stimulated by ADAPT-232 in nueroglia cells augments tolerance and adaptation to stress

A Panossian 1, G Wikman 1, P Kaur 2, A Asea 2
  • 1Swedish Herbal Institute (SHI) Research and Development, Spårvägen 2, SE-432 96Åskloster, Sweden
  • 2Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508 USA

We demonstrated that ADAPT-232, a fixed combination of adaptogens Eleutherococcus senticosus root extract, Schisandra chinensis berry extract, Rhodiola rosea root extract SHR-5, and its active constituent salidroside stimulated the expression of NPY and Hsp72 in isolated human neurolgia cells. We further validated the central role of NPY in experiments in which pre-treatment of human neuroglia cells with NPY-siRNA and HSF1-siRNA resulted in the significant suppression of ADAPT-232-induced NPY and Hsp72 release. Our studies suggest that the stimulation and release of the stress hormones, NPY and Hsp72, into systemic circulation is an innate defense response against mild stressors (ADAPT-232), which increase tolerance and adaptation to stress.