The inhibiotry effect of honokiol, a natural plant product, on vestibular schwannoma cells

JD Lee; MK Park; SH Byeon; JY Kim

doi:10.1055/s-0032-1320613

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Planta Med 2012; 78 - PF66
DOI: 10.1055/s-0032-1320613

The inhibiotry effect of honokiol, a natural plant product, on vestibular schwannoma cells

JD Lee ¹, MK Park ¹, SH Byeon ¹, JY Kim ¹

¹Department of Otorhinolaryngology-Head and Neck surgery, Soonchunhyang University College of Medicine, Bucheon, Korea

Congress Abstract

As the molecular biology of vestibular schwannoma (VS) is better understood, new means of targeting the pathways involved for intervention in schwannoma cells are being developed. Honokiol, a bioactive constituent of Magnolia officinalis, has attracted attention due to its diverse biological effects. Honokiol exhibited significant anti-proliferative activity in a dose-dependent manner on HEI 193 cells. Significant apoptosis was detected on schwannoma cells with 7 µg/mL (IC₅₀) honokiol. Western blot analysis showed significant inhibition of ERK phosphorylation.