Planta Med 2012; 78 - PF51
DOI: 10.1055/s-0032-1320598

ID1201, chinaberry extract, decreases β-amyloid and attenuates memory deficit

JH Kim 1, JY Kim 1, MJ Lee 1, JS Yoo 1, EK Park 1, YJ Jeon 1, SW Yeon 1, BY Hwang 2, JH Kang 1
  • 1ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong 445–710, Korea
  • 2College of Pharmacy, Chungbuk National University, Cheongju 361–763, Korea

We newly found that chinaberry (fruits of Melia toosendan) extracts potently block production of β-amyloid, which is implicated as a cause of Alzheimer's disease, through PI3-kinase mediated α-secretase activation in vitro. Toosendanin, a major triterpenoid in chinaberry, is isolated as an active compound. In consideration of safety and efficacy, we finally choose ID1201, 30% ethanol extract of chinaberry. In studies in vivo, we identified that the treatment with 100mg/kg ID1201 not only significantly reduced β-amyloid in the brains of 5X FAD mice but also ameliorated scopolamine induced amnesia. Taken together, our results present the possibility that ID1201 may have potential for the treatment of Alzheimer's disease. Currently, ID1201 is under preclinical trial.

Toosendanin

Inhibition of β-amyloid plaques in the brain tissue of 5X FAD mice