Evaluation of the antiangiogenic and anti-parasitic activities of flavonoids from gardenia species and their modified analogues
Dedicated to the memory of Pr François Tillequin
The structural similarity of methoxylated flavonoids with the antiangiogenic agent Combretastatin A4 makes them good candidates as potential inhibitors of tumour blood vessels. In addition, some of these secondary metabolites showed noticeable anti-parasite activities against Plasmodium and Trypanosome. In this context, six flavone derivatives, isolated from the glutinous exudate of flowering buds of two species from New-Caledonia Gardenia urvillei and Gardenia oudiepe, and their nine modified analogues were evaluated for antiangiogenic and anti-parasitic activities. Some structure-activity relationship are then proposed.