Planta Med 2012; 78 - PD152
DOI: 10.1055/s-0032-1320510

Tyrosinase inhibition and free radical scavenging activities from Amazonian Bauhinia coronata

P Moraes dos Santos 1, PD Oliveira de Almeida 2, ES Lima 2, VF da Veiga Junior 1
  • 1Department of Chemistry, Federal University of Amazonas, Av. Gal. Rodrigo Octávio, 6.200, Coroado, Manaus-AM, Brazil
  • 2Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Rua Alexandre Amorin, 300, Aparecida, Manaus-AM, Brazil

Bauhinia species (Fabaceae) are a very common ethnopharmacological resource used in Brazil to treat diabetes. The hypoglicemiant activity of extracts containning kaempferitrin and other phenolic compounds is already confirmed and several cosmetic uses have been searched. Amazonian Bauhinia species are still poorly known and studied. The aim of this work was to verify the free radical scavenging (DPPH) and tyrosinase inhibition activities of methanolic extracts obtained from twigs (BCB) and leaves (BCL) from the Amazonian Bauhinia coronata Benth. The tyrosinase IC50 observed to BCB was 696.97±1.27 ug/mL, but to BCL the IC50 was 209.65±0.91 ug/mL a very interesting result compared to the positive control kojic acid 56.60±0.16 ug/mL. The free radical scavenging activities using DPPH observed were 15.94±1.97 ug/mL to BCB; and 14.01±2.71 ug/mL to BCL, again, a promising result compare to the positive control, quercetin (2.57±0.10 ug/mL). These results demonstrated a potential utilization of B. coronata extracts in cosmetic formulation aiming for anti-aging products.