Planta Med 2012; 78 - PD135
DOI: 10.1055/s-0032-1320493

Antibacterial activity of the methanolic extract of Hyptis atrorubens (Lamiaceae)

A Abedini 1, V Roumy 1, C Neut 2, M Biabiany 3, H Joseph 3, S Sahpaz 1, F Bailleul 1, T Hennebelle 1
  • 1Laboratoire de Pharmacognosie, EA 4481, Université de Lille, 59006 Lille, France
  • 2Laboratoire de Bactériologie, U995, Université de Lille, 59006 Lille, France
  • 3APLAMEDAROM, Association des Plantes Médicinales et Aromatiques de Guadeloupe, Mompierre, 97111 Morne-à-l'eau, France

The leaves and stems of Hyptis atrorubens Poit. (Lamiaceae) were collected in Guadeloupe. The methanol extract was tested at six concentrations (10mg/mL, 5mg/mL, 2.5mg/mL, 1.2mg/mL, 0.6mg/mL and 0.3mg/mL) against a panel of pathogenic Gram-positive and Gram-negative bacteria in vitro. This methanolic extract demonstrated antibacterial activity against two Gram-positive bacteria (Staphylococcus epidermidis and Enterococcus faecalis), and two Gram-negative bacteria (Burkholderia cepacia and Stenotrophomonas maltophilia) at all of the concentrations. Bioautography enabled the obtention and identification of two antibacterial compounds from this plant: rosmarinic acid and methyl rosmarinate. This work supports the recognition of H. atrorubens, a traditional remedy in French West Indies, as a medicinal plant in France.