Multiple enzyme inhibition potential of Butea superba for management of erectile dysfunction
Inhibitors of Rho-kinase II (ROCK-II), soluble epoxide hydrolase (sEH) and Phosphodiesterase type 5 (PDE5) enzymes have been reported to relax corpus cavernosum smooth muscles and increase intracavernous pressure. Plant extract capable of inhibiting the enzymes, which might be useful in management of erectile dysfunction (ED) were screened using commercially available kits.
Methanolic extract of Butea superba (MEBS) at 50µg/mL was found to inhibit ROCK-II, sEH and PDE5 upto 51.8±0.5, 24.73±0.1 and 51.9±0.3% respectively. Erectile function increasing potential of Butea superba extract is reported in rats as well as humans.
Hence, erectile function increasing activity of MEBS might be due to multiple enzyme inhibition potential of the extract.