Acetylcholinesterase and butyrylcholinesterase inhibition by Phormopsis Sp methanol extract and its isolated compounds

RM Marçal; R Santos; MFC Santos; GH Silva

doi:10.1055/s-0032-1320451

Planta Medica, Table of Contents

Acetylcholinesterase and butyrylcholinesterase inhibition by Phormopsis Sp methanol extract and its isolated compounds

RM Marçal ¹, R Santos ¹^,², MFC Santos ², GH Silva ²

¹LAPHET, DFS, Campus São Cristóvão, Universidade Federal de Sergipe; Av: Marechal Rondon, S/N, CEP 49100–000, São Cristóvão, SE, Brazil
²Laboratory of Organic Chemistry, Campus Itabaiana, Universidade Federal de Sergipe; Av: Marechal Rondon, S/N, CEP 49100–000, São Cristóvão, SE, Brazil

Abstract

In the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian flora, leaves of Harconia speciosa Gomes were submitted to isolation of endophytes. A Phormopsis sp was isolated from H. speciosa and its methanol extract (MEP) was evaluated as AChE and BuChE inhibitor. Triptophol and 5-methylmellein, isolated from MEP, have also been evaluated as AChE and BuChE inhibitor. Cholinesterase activity was evaluated by Elmman's method. Neostigmine was used as positive control. The results of the cholinesterase inhibition in the presence of MEP (A), triptophol (B), and 5-methylmellein (C) will be presented.