Planta Med 2012; 78 - PD78
DOI: 10.1055/s-0032-1320436

Might paretin have effect against tau protein?

A Cornejo 1, 2, C Areche 3, E Perez 4, B Sepulveda 5, RB Maccioni 2, 6
  • 1Departamento de Tecnología Médica, Facultad de Medicina, Universidad Mayor
  • 2Centro International de Biomedicina (ICC)
  • 3Departmento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
  • 4Departamento de Química, Pontificia Universidad Católica de Chile, Santiago, Chile
  • 5Departamento de Química, Universidad Andrés Bello, Viña del Mar, Chile
  • 6Laboratorio de Biología Celular, Molecular y Neurociencias, Facultad de Ciencias, Universidad de Chile

Alzheimer disease (AD) is the most common neurodegenerative disorder involving amyloid-β and neurofibrillary tangles, composed by hyperphosphorylated tau protein. We investigate parietin 1 in the context of their action to prevent tau alterations in the etiopathogenesis of AD. Xanthoria ectaneoides and Arthopyrenia saxicola, two marine lichens, were studied for the first time given parietin as the major compound, ergosterol peroxide 2 and 2-hydroxyethylacetate 3. The effects of parietin against the aggregation process of tau protein will be presented and discussed.

Financial support:

VID (I-09/18–2, Universidad de Chile), Fondecyt Iniciacion N° 11110241, FONDECYT grant 1110373 and the International Center for Biomedicine.