Might paretin have effect against tau protein?
Alzheimer disease (AD) is the most common neurodegenerative disorder involving amyloid-β and neurofibrillary tangles, composed by hyperphosphorylated tau protein. We investigate parietin 1 in the context of their action to prevent tau alterations in the etiopathogenesis of AD. Xanthoria ectaneoides and Arthopyrenia saxicola, two marine lichens, were studied for the first time given parietin as the major compound, ergosterol peroxide 2 and 2-hydroxyethylacetate 3. The effects of parietin against the aggregation process of tau protein will be presented and discussed.
VID (I-09/18–2, Universidad de Chile), Fondecyt Iniciacion N° 11110241, FONDECYT grant 1110373 and the International Center for Biomedicine.