Planta Med 2012; 78 - PD70
DOI: 10.1055/s-0032-1320428

Cytotoxic activity, acute and sub-acute toxicity of root extracts of Corrigiola Telephiifolia Pourr

L Doudach 1, 2, B Meddah 1, M Faouzi 1, L Chabraoui 3, L Benbacer 4, M Abouabdellah 3, A Elomri 2, Y Cherrah 1
  • 1University Mohammed V Souissi. Faculty of Medicine and Pharmacy, Laboratory of Pharmacology and Toxicology, 10000 Rabat, Morocco
  • 2Université de Rouen, CNRS UMR 6014, C.O.B.R.A. UFR Médecine-Pharmacie, 22 Boulevard Gambetta, 76183 Rouen, France
  • 3Laboratoire Central de Biochimie, CHU Ibn Sina Rabat
  • 4Unité de Biologie et Recherche Médicale CNESTEN, BP 1382 RP, 10001 Rabat, Maroc

C. telephiifolia is an herbal plant commonly used in Moroccan folk medicine for treatment of many disorders. In the present study, we investigated cytotoxic activity by an in vitro assay system of growth inhibition against a human cancer cell line (HeLa), the results demonstrated that CH2Cl2 extract show a moderate cytotoxicity. The acute and sub-acute toxicity of the methanolic extract was evaluated. For acute toxicity, a single oral administration was performed at a dose of 2g/kg body weight (6 females, 6 males mice). The study of sub-acute toxicity was evaluated by daily oral (5 females, 5 males) with doses from 10 to 500mg/kg/day for 45 days. No mortality or signs of toxicity were observed in the acute study. Mice were analyzed for final body and organ weights, necropsy, and blood chemical and histopathological parameters. In the 40 day study in mice the extract at 10, 50mg/kg/day showed no toxicity, mortality, macroscopic or microscopic change of internal organs or tissues in comparison with the control group. The extracts of C. telephiifolia showed a cytotoxic activity with low toxicity. They are good candidates for further investigations in the fields of new anticancer drugs discovery.