Planta Med 2012; 78 - PD61
DOI: 10.1055/s-0032-1320419

Effects of peat distillates in adjuvant arthritis of rats

AN Shikov 1, MN Makarova 1, 2, MA Kovaleva 1, 2, ON Pozharitskaya 2, VG Makarov 1, GI Djachuk 1
  • 1North-West State Medicinal University named after I.I. Mechnikov, 47, Piskarevsky pr., 195067, St-Petersburg, Russia
  • 2St.-Petersburg Institute of Pharmacy, 56, Bolshaja Porochovskaya, POBox 16, 195248, St-Petersburg, Russia

In continuation of our studies on efficacy of peat distillates [1], anti-inflammatory effects in model of adjuvant arthritis (AA) were studied.

Samples of peat were collected in October 2010 by Dr. N. Demidova. The peat was distilled with steam. AA was induced by a single injection of 0.l mL of Freund's adjuvant in the aponeurosis of right paw of rats. After 5 days rats were injected with peat distillates (1.5, 3.0 and 4.5 mL) during 21 days. Ibuprofen was used as positive control. The edema volume was determined using oncometric method, antipyretic and analgesic effects were registered [2].

Anti-edema effect was not registered. The antipyretic effect of peat distillate (3.0 mL) was registered after 9 days of application and after 21 days the temperature was practically normalized. The response time of rats in hot plate test was increased 2–2.5 -fold compared to the control group after 21 days. Arthritic lesions found in roentgenographic examinations were also inhibited in peat distillate-treated animals.

The findings suggest that peat distillates may used for the treatment of AA.

References: 1. Makarova et al. (2011), Planta Med., 77, 1411; Shikov et al. (2010) Phytomedicine, 17, 463–468.

Acknowledgements: the study was supported by FORESTSPECS project, grant agreement 227239.