Planta Med 2012; 78 - PD38
DOI: 10.1055/s-0032-1320396

Pharmacomodulation of Meiogynin A, a dimeric sesquiterpenoid inhibiting BCL-XL and BAK interaction

J Dardenne 1, A Pujals 2, C Colas 1, N Birlirakis 1, J Wiels 2, V Dumontet 1, C Geny 1, B Iorga 1, F Guéritte 1, F Roussi 1
  • 1Institut de Chimie de Substances Naturelles, UPR 2301, CNRS, 9198, Gif-sur-Yvette
  • 2UMR 8126, CNRS Institut Gustave Roussy, 94805, Villejuif cedex

A new dimeric sesquiterpenoid, meiogynin A 1, was recently isolated in our team. This compound acts as an antagonist of the Bcl-xL/Bak association. We performed its biomimetic total synthesis as well as those of analogues guided by molecular modelling and in proteo NMR studies. The chemical and biological results will be presented.