Pharmacomodulation of Meiogynin A, a dimeric sesquiterpenoid inhibiting BCL-XL and BAK interaction
A new dimeric sesquiterpenoid, meiogynin A 1, was recently isolated in our team. This compound acts as an antagonist of the Bcl-xL/Bak association. We performed its biomimetic total synthesis as well as those of analogues guided by molecular modelling and in proteo NMR studies. The chemical and biological results will be presented.