Versatile selective kinase inhibitors: Chemistry and biology of indirubins
In an effort to identify new kinases inhibitors, natural and synthetic indirubins have been tested. This full SAR study led to the discovery of versatile selective kinases inhibitors according to the substitutions degree. This inhibition selectivity led to diverse biological activities e.g. stem cell pluripotency preservation1 or in vivo anti-tumor activities.
1: N. Sato et al, Nature Med, 2004, 10, 55–63.