Planta Med 2012; 78 - PD32
DOI: 10.1055/s-0032-1320390

(±)-Licarina-A loaded PLGA nanoparticles: Preparation and in vitro schistosomicidal activity for controlled release

TC Lima 1, WR Cunha 1, LG Magalhães 1, JK Bastos 2, AC Pereira 1, 2, PP Luz 1, MLA e Silva 1
  • 1Universidade de Franca, Franca, SP, Brazil
  • 2Universidade de São Paulo, Ribeirão Preto, SP, Brazil

The aim of this work was incorporation of (±)-licarina-A 1 into the PLGA particles were carried out by emulsion/solvent evaporation method. The obtained particles were centrifuged and dried out by lyophilization. The nanoparticles were characterized by FESEM and the amount of 1 was quantified by UV-Vis spectroscopy. Preliminary bioassay results indicate that 1 possesses in vitro schistosomicidal activity against adult worms couples of Schistosoma mansoni at 200µM, leading to 100% of couples separation and completely motor activity reducing. In vitro schistosomicidal activity of (±)-licarina-A-loaded PLGA nanoparticles are in progress in order to elucidate a possible improved and prolonged schistosomicidal action. Sponsors: FAPESP, CNPq and CAPES