Diterpenes isolated from Euphorbia Sp that promote neurogenesis from neural stem cells
Protein kinase C isozymes (PKCs) are important signal transducers through an endogenous or exogenous activating compound. As they are involved in many biological events, PKCs are attractive targets in drug design for treatment of cancer, AIDS or Alzheimer's disease. Based on previous results obtained by our research group and on structural similarities with non-tumor promoter diterpenes such as prostratine, compounds with lathyrane skeleton have been designed as molecules agonist of proteins kinase C (PKC). Ingols 1-2 and lathyranes 3-5 were isolated from Euphorbia sp. Their isolation and their capability to promote neural stem cells proliferationwill be presented.