Planta Med 2012; 78 - PD31
DOI: 10.1055/s-0032-1320389

Diterpenes isolated from Euphorbia Sp that promote neurogenesis from neural stem cells

ME Flores-Giubi 1, 2, N Geribaldi 1, M Murillo-Carretero 1, A Macías-Sánchez 2, M Daoubi 2, F Echeverri 3, C Castro 1, R Hernández-Galán 2
  • 1Área de Fisiología, Facultad de Medicina. Universidad de Cádiz, Spain
  • 2Departamento de Química Orgánica, Facultad de Ciencias. Universidad de Cádiz, Spain
  • 3Grupo de Química Orgánica de Productos Naturales, Instituto de Química. Universidad de Antioquia, Medellín, Colombia

Protein kinase C isozymes (PKCs) are important signal transducers through an endogenous or exogenous activating compound. As they are involved in many biological events, PKCs are attractive targets in drug design for treatment of cancer, AIDS or Alzheimer's disease. Based on previous results obtained by our research group and on structural similarities with non-tumor promoter diterpenes such as prostratine, compounds with lathyrane skeleton have been designed as molecules agonist of proteins kinase C (PKC). Ingols 1-2 and lathyranes 3-5 were isolated from Euphorbia sp. Their isolation and their capability to promote neural stem cells proliferationwill be presented.