Planta Med 2012; 78 - PD14
DOI: 10.1055/s-0032-1320372

Antiproliferative withanolides from the solanaceae: A structure-activity study

H Zhang 1, A Samadi 2, R Gallagher 1, R Gollapudi 1, MS Cohen 2, BN Timmermann 1
  • 1Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
  • 2Department of Surgery, University of Kansas Medical Center, Kansas, KS 66160, USA

The antiproliferative activities for all published withanolides from members of the family Solanaceaewere summarized. The structure-activity relationship analysis (SARA) confirmed the importance of the presence of 2-en-1-one in ring A; 5β,6β-epoxy or 5α-chlorine-6β-hydroxy in ring B; and nine carbon side chain with a lactone moiety for cytotoxic activity. Conversely, the SARA indicated that the -OH or -OR groups at C-4, 7, 11, 12, 14, 15, 16, 17, 18, 19, 20, 23, 24, 27 were not contributors to the observed activities.