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Planta Med 2012; 78 - PB14
DOI: 10.1055/s-0032-1320343
DOI: 10.1055/s-0032-1320343
Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger
We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.