Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 2012; 78 - PB9
DOI: 10.1055/s-0032-1320338
DOI: 10.1055/s-0032-1320338
The biosynthesis of mensacarcin and the importance of MSNO8
Mensacarcin, a hexahydroanthracene, is produced by Streptomyces bottropensis and shows cytotoxic activity. Subsequent knockouts of different genes in the PKSII biosynthetic gene cluster gave more insights into the biosynthesis of mensacarcin. Recently we could show, that MsnO8 catalyzes the epoxide formation in the side chain of mensacarcin [1]. The structure of this protein was solved by X-ray crystallography. To complete the elucidation of the mensacarcin biosynthesis we are currently inactivating further genes. Eventually, we will be able to use this knowledge for combinatorial biosynthesis to produce new anticancer agents.
1. Probst, K., PhD thesis. 2011, University of Freiburg.