Bioactives products from leaves endophytes

Leaves endophytes contribute to the natural defense of plant leaves, preventing both herbivory and invasion from superficial pathogens. It was therefore postulated that these microbes should produce antimicrobial and/or cytotoxic compounds. The isolated microorganisms belong to 14 different orders, the xylariales being the most represented (35 isolates, A). More than 20% of the extracts were considered active against at least one target (B) and the most active ones were produced on the large scale for bioguided fractionation, the results of which will be presented. Overall, this work demonstrates that endophytes are involved in mutualistic interactions with higher plants, contributing to their defense system. These interactions can inspire the discovery of new drug candidates.