This work describes a rapid and convenient synthesis of 3,5-disubstituted 2-chloropyridines
from various α,β-unsaturated ketoximes utilizing the Vilsmeier reaction under microwave
irradiation. The 3,5-disubstituted 2-chloropyridines were further converted into tetrazolo[1,5-a]pyridines by a microwave-mediated solid-phase reaction. The products were isolated
in good yields within a very short reaction time.
Key words
2-chloropyridine - Vilsmeier reaction - tetrazolo[1,5-
a]pyridine - microwave