Catalytic Asymmetric Cyclopropanation with Diazooxindole
Received: 12 October 2012
Accepted after revision: 12 November 2012
11 December 2012 (eFirst)
The first catalytic asymmetric cyclopropanation using styrene and diazooxindole was achieved with Rh2(S-PTTL)4. The reaction proceeded smoothly with 1 mol% catalyst loading to provide a good yield of the biologically important spiro-cyclopropyloxindole product with moderate to good enantioselectivity and excellent diastereoselectivity.