Catalytic Asymmetric Cyclopropanation with Diazooxindole

Abstract

The first catalytic asymmetric cyclopropanation using styrene and diazooxindole was achieved with Rh₂(S-PTTL)₄. The reaction proceeded smoothly with 1 mol% catalyst loading to provide a good yield of the biologically important spiro-cyclopropyl­oxindole product with moderate to good enantioselectivity and excellent diastereoselectivity.

Key words

asymmetric catalysis - spiro compounds - carbenoids - cyclopropanation - oxindole

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