Expanding Structural Diversity; Removable and Manipulable Directing Groups for C–H Activation

Chengming Wang; Yong Huang

doi:10.1055/s-0032-1317714

Synlett, Table of Contents

Synlett 2013; 24(2): 145-149
DOI: 10.1055/s-0032-1317714

synpacts

Expanding Structural Diversity; Removable and Manipulable Directing Groups for C–H Activation

Authors

Chengming Wang

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen, 518055, P. R. of China Fax: +86(755)26033174 Email: huangyong@pkusz.edu.cn
Yong Huang*

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen, 518055, P. R. of China Fax: +86(755)26033174 Email: huangyong@pkusz.edu.cn

Abstract

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Abstract

The need to use a static directing group represents a major limitation for the emerging field of ortho-selective C–H activation and functionalization. Chemistry was recently developed that allowed partial removal or minor transformations for certain directing groups. Our recent work demonstrated that triazenes were a class of excellent directing groups for C–H activation/functionalization, and subsequent chemical manipulations generated key compounds with synthetic versatility.

Key words

C–H activation - directing groups - transition metals - catalysis - protecting groups

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References

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