Pd-Catalyzed Cascade Reaction for the Synthesis of 2-Substituted Indoles

Jagannath Jadhav; Vipul Gaikwad; Rajanikant Kurane; Rajashri Salunkhe; Gajanan Rashinkar

doi:10.1055/s-0032-1317320

Synlett, Inhaltsverzeichnis

Synlett 2012; 23(17): 2511-2515
DOI: 10.1055/s-0032-1317320

letter

Pd-Catalyzed Cascade Reaction for the Synthesis of 2-Substituted Indoles

Jagannath Jadhav

Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Fax: +91(231)2692333 eMail: gsr_chem@unishivaji.ac.in

,

Vipul Gaikwad

Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Fax: +91(231)2692333 eMail: gsr_chem@unishivaji.ac.in

,

Rajanikant Kurane

Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Fax: +91(231)2692333 eMail: gsr_chem@unishivaji.ac.in

,

Rajashri Salunkhe

Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Fax: +91(231)2692333 eMail: gsr_chem@unishivaji.ac.in

,

Gajanan Rashinkar*

Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Fax: +91(231)2692333 eMail: gsr_chem@unishivaji.ac.in

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Abstract

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Abstract

An efficient cascade methodology toward the synthesis of 2-substituted indoles has been developed. The transformation proceeds via a palladium-catalyzed cross-coupling reaction of o-nitrobenzyl cyanides with boronic acids. The use of Fe as co-catalyst during the course of reaction employs significant enhancement in reaction rates. The developed protocol allows for the unprecedented use of arylboronic acids as coupling partners for constructing 2-substituted indoles.

Key words

cascade synthesis - 2-substituted indoles - palladium-catalyzed cross-coupling reaction

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Referenzen

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