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Synthesis 2012; 44(23): 3551-3578
DOI: 10.1055/s-0032-1316797
DOI: 10.1055/s-0032-1316797
review
Advances in the Synthesis of Morpholin-3-ones and Morpholin-2-ones
Weitere Informationen
Publikationsverlauf
Received: 24. Juli 2012
Accepted after revision: 17. September 2012
Publikationsdatum:
05. November 2012 (online)
Abstract
This review covers advances in the synthesis of morpholin-3-ones and morpholin-2-ones. Besides the classical approaches for the preparation of both heterocycles that utilize intermolecular cyclizations of reactants or oxidation of morpholine and its derivatives, strategies employing various ring-expansion reactions using smaller heterocyclic substrates or multicomponent reactions are described.
1 Introduction
2 Synthesis of Morpholin-3-ones
2.1 By Formation of Two Bonds
2.2 By Formation of One Bond
2.3 By Introduction of Substituents
3 Synthesis of Morpholin-2-ones
3.1 By Formation of Two Bonds
3.2 By Formation of One Bond
3.3 By Introduction of Substituents
4 Conclusion
-
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