A Synthesis of the Pseudopterosin A–F Aglycone
Received: 24 April 2012
Accepted: 13 June 2012
08 August 2012 (eFirst)
The synthesis of the pseudopterosin A–F aglycone from 3-methylcatechol features (a) the use of asymmetric Ireland–Claisen and aryl Claisen rearrangements to install three of the four stereocentres present in the molecule and (b) an A→AB→ABC annulation strategy using ring-closing metathesis and cationic cyclisation reactions as the key steps.