AJP Rep 2012; 02(01): 055-062
DOI: 10.1055/s-0032-1316465
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

In Utero Detection of Retinoblastoma with Fetal Magnetic Resonance and Ultrasound: Initial Experience

Lisa B. Paquette
1   Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, California
,
David Miller
2   Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California
,
Hollie A. Jackson
3   Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California
,
Thomas Lee
4   Division of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, California
,
Linda Randolph
5   Division of Medical Genetics, Children's Hospital Los Angeles, Los Angeles, California
,
A. Lynn Murphree
4   Division of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, California
,
Ashok Panigrahy
6   Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
› Author Affiliations
Further Information

Publication History

17 January 2012

03 March 2012

Publication Date:
16 July 2012 (online)

Abstract

Purpose Our aim was to evaluate and compare the ability of prenatal ultrasound (US) and fetal magnetic resonance imaging (MRI) to detect retinoblastoma lesions in utero.

Methods Fetuses at risk for having bilateral retinoblastoma were enrolled in this prospective study. High-resolution US of the fetal eye was performed at 16 to 18 weeks' gestation, every 4 weeks until 32 weeks, then every 2 weeks until delivery. Fetal MRIs were performed every 8 weeks starting at 16 to 18 weeks of gestation. An exam under anesthesia (EUA) was performed postnatally, the gold standard of this study. Lesions were classified as being elevated or minimally elevated based upon their morphology.

Results Of six fetuses suspected or confirmed to be at risk for developing bilateral retinoblastoma, one had tumors on her first postnatal EUA exam. A total of two minimally elevated lesions were seen by the EUA but not detected prenatally by imaging. One elevated lesion (2 mm in height) identified by postnatal EUA was initially identified by prenatal US. Fetal MRI did not detect any lesions.

Conclusion Both prenatal US and fetal MRI are limited in the detection of minimally elevated retinoblastoma lesions. Prenatal US appears to be more sensitive than fetal MRI in the detection of elevated retinoblastoma lesions.

 
  • References

  • 1 Barkhof F, Smeets M, van der Valk P , et al. MR imaging in retinoblastoma. Eur Radiol 1997; 7: 726-731
  • 2 de Graaf P, Barkhof F, Moll AC , et al. Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology 2005; 235: 197-207
  • 3 Schueler AO, Hosten N, Bechrakis NE , et al. High resolution magnetic resonance imaging of retinoblastoma. Br J Ophthalmol 2003; 87: 330-335
  • 4 Honavar SG. Orbital retinoblastoma. In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 477-483
  • 5 Lyle CE, Rodriguez-Galindo C, Wilson MW. Trilateral retinoblastoma. In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 438-440
  • 6 De Potter P. Imaging techniques. In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 507-516
  • 7 Cunningham FG, Leveno KJ, Bloom SJ , et al. Williams Obstetrics, 22nd ed. New York: McGraw Hill; 2005: 349-365
  • 8 Callen PW. Ultrasonography in Obstetrics and Gynecology, 3rd ed. Philadelphia: W.B. Saunders; 1994: 8-16
  • 9 Mattison DR, Kay HH, Miller RK , et al. Magnetic resonance imaging: a noninvasive tool for fetal and placental physiology. Biol Reprod 1988; 39: 39-49
  • 10 Maat-Kievit JA, Oepkes D, Hartwig NG, Vermeij-Keers C, van Kamp IL, van de Kamp JJ. A large retinoblastoma detected in a fetus at 21 weeks of gestation. Prenat Diagn 1993; 13: 377-384
  • 11 Salim A, Wiknjosastro GH, Danukusumo D, Barnas B, Zalud I. Fetal retinoblastoma. J Ultrasound Med 1998; 17: 717-720
  • 12 Toi A, Sutherland J, Gallie B , et al. Evaluation of the fetus at risk for retinoblastoma: what is the role of prenatal ultrasound?. Ultrasound Med Biol 2003; 29: S137
  • 13 Finger PT, Khoobehi A, Ponce-Contreras MR, Rocca DD, Garcia Jr JP. Three dimensional ultrasound of retinoblastoma: initial experience. Br J Ophthalmol 2002; 86: 1136-1138
  • 14 Singh AD, Balmer A, Munier F. Retinocytoma or retinoma. In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 487-490
  • 15 Brisse HJ, Lumbroso L, Fréneaux PC , et al. Sonographic, CT, and MR imaging findings in diffuse infiltrative retinoblastoma: report of two cases with histologic comparison. AJNR Am J Neuroradiol 2001; 22: 499-504
  • 16 Traboulsi EI, Heur M, Singh A. Tumors of the retinal pigment epithelium. In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 358-365
  • 17 Singh AD, Traboulsi E, Schoenfield L. Neuro-oculocutaneous syndromes (phakomatoses). In: Singh AD, Damato BE, Pe'er J, Murphree AL, Perry JD, eds. Clinical Ophthalmic Oncology. Philadelphia: W.B. Saunders; 2007: 385-401
  • 18 Kliegman RM, Behrman RE, Jenson HB , et al. Nelson Textbook of Pediatrics, 18th ed. W.B. Saunders: Philadelphia; 2007: 2151-2152