Regenerative Therapies in Neonatology: Clinical Perspectives

Abstract

Regenerative therapy based on stem cells is applied as standard therapy in pediatric oncology. Furthermore, they are frequently used to treat immunodeficiency disorders of infants. For severe neonatal diseases, e. g. hypoxic-ischemic encephalopathy in term neonates or bronchopulmonary dysplasia in preterm infants, animal models have been established. According to some first preclinical results stem cell administration appears as a promising tool to improve the clinical outcome in high-risk infants. Provided the benefit of regenerative therapies can further be evaluated in appropriate preclinical neonate models, carefully controlled clinical trials to assess the significance of regenerative therapies, such as autologous stem cell administration, are indicated.

Zusammenfassung

Regenerative Therapien sind Standard bei onkologischen pädiatrischen Erkrankungen sowie Immundefekten, wobei sowohl Stammzellen als auch Wachstumsfaktoren eingesetzt werden. In der Neonatologie wurden bislang nur tierexperimentell bei hypoxisch-ischämischer Enzephalopathie und bei der bronchopulmonalen Dysplasie Stammzellen mit Erfolg appliziert. Diese Ergebnisse legen nahe, dass bei Bestätigung dieser Befunde in weiteren experimentellen Studien kontrollierte Studien an Hochrisikokindern notwendig sind. Der Einsatz von autologen Stammzellpräparaten ist hierbei ein erster Schritt, um die Bedeutung der regenerativen Therapie in der Neonatologie zu evaluieren.

Key words

regenerative therapy - neonate - perinatal brain injury - bronchopulmonary dysplasia - cellular therapy

Schlüsselwörter

regenerative Therapie - Neugeborenes - perinatale Hirnschädigung - bronchopulmonale Dysplasie - Zelltherapie

• References

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