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Planta Med 2012; 78(15): 1667-1675
DOI: 10.1055/s-0032-1315239
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Steroidal Saponins and Sterol Glycosides from Paris polyphylla var. yunnanensis

Xia Wu
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
,
Lei Wang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
,
Guo-Cai Wang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
,
Hui Wang
3   School of Medicine, Jinan University, Guangzhou, PR China
,
Yi Dai
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
,
Wen-Cai Ye
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
,
Yao-Lan Li
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China
› Author Affiliations
Further Information

Publication History

received 17 January 2012
revised 13 July 2012

accepted 23 July 2012

Publication Date:
24 August 2012 (online)

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Abstract

Four new steroidal saponins, pariposides A–D (1–4), and two new sterol glycosides, pariposides E–F (5-6), along with eight known steroidal saponins (7-14), two known sterol glycosides (15–16), and two known ecdysteroids (17–18), were isolated from the roots of Paris polyphylla var. yunnanensis. Among them, compounds 1–4 are the first spirostanol saponins with a peroxy group located between C-5 and C-8 of the aglycone. Their structures were determined by detailed spectroscopic analyses and chemical methods. All the isolated compounds were evaluated for their in vitro cytotoxicities against human nasopharyngeal carcinoma epithelial (CNE) cells, and steroidal saponins 7, 11, 13, and 14 showed a potent antiproliferative effect on CNE cells with IC50 values of 9.2, 4.7, 11.1, and 2.7 µM, respectively.

Key words

Paris polyphylla var. yunnanensis - Liliaceae - steroidal saponin - sterol glycoside - cytotoxic activities

Supporting Information

 

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