Endometritis beim Rind – Übersicht zur Diagnostik und Therapie

Endometritiden stellen eine der häufigsten postpartalen Erkrankungen bei Milchkühen dar. Sowohl zur Erkennung als auch zur Behandlung der Erkrankung stehen in der tierärztlichen Praxis verschiedene Möglichkeiten zur Verfügung. Dieser Artikel fasst den aktuellen Stand der Diskussion über Diagnostik und Therapie chronischer, klinischer sowie subklinischer Endometritiden zusammen.

• Literatur

• 1 Barlund CS, Carruthers TD, Waldner CL, Palmer CW. A comparison of diagnostic techniques for postpartum endometritis in dairy cattle. Theriogenol 2008; 69: 714-723
• 2 Cheong SH, Nydam DV, Galvão KN, Crosier BM, Gilbert RO. Cow-level and herd-level risk factors for subclinical endometritis in lactating Holstein cows. J Dairy Sci 2011; 94: 762-770
• 3 Drillich M, Raab D, Wittke M, Heuwieser W. Treatment of chronic endometritis in dairy cows with an intrauterine application of enzymes. A field trial. Theriogenol 2005; 63: 1811-1823
• 4 Drillich M, Tesfaye D, Rings F, Schellander K, Heuwieser W, Hoelker M. Effects of polymorphonuclear neutrophile infiltration into the endometrial environment on embryonic development in superovulated cows. Theriogenol 2012; 77: 570-578
• 5 Dubuc J, Duffield TF, Leslie KE, Walton JS, Leblanc SJ. Risk factors for postpartum uterine diseases in dairy cows. J Dairy Sci 2010; 93: 5764-5771
• 6 Falkenberg U, Heuwieser W. Influence of time of initiation of a prostaglandin F2alpha protocol in dairy cows with puerperal endometritis. Deut Tierärztl Wochenschr 2005; 112: 252-256
• 7 Fischer C, Drillich M, Odau S, Heuwieser W, Einspanier R, Gabler C. Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis. Reprod Fertil Dev 2010; 22: 818-829
• 8 Gabler C, Drillich M, Fischer C, Holder C, Heuwieser W, Einspanier R. Endometrial expression of selected transcripts involved in prostaglandin synthesis in cows with endometritis. Theriogenol 2009; 71: 993-1004
• 9 Gabler C, Fischer C, Drillich M, Einspanier R, Heuwieser W. Time-dependent mRNA expression of selected pro-inflammatory factors in the endometrium of primiparous cows postpartum. Reproductive Biology and Endocrinology 2010; 8: 152
• 10 Galvão KN, Flaminio MJBF, Brittin SB, Sper R, Fraga M, Caixeta L, Ricci A, Guard CL, Butler WR, Gilbert RO. Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows. J Dairy Sc 2010; 93: 2926-2937
• 11 Gilbert RO, Shin ST, Guard CHL, Erb HN, Frajblat M. Prevalence of endometritis and its effects on reproductive performance of dairy cows. Theriogenol 2005; 64: 1879-1888
• 12 Heuwieser W, Tenhagen BA, Tischer M, Lühr J, Blum H. Effect of three programmes for the treatment of endometritis on the reproductive performance of a dairy herd. Vet Rec 2000; 18: 338-341
• 13 Kasimanickam R, Duffield TF, Foster RA, Gartley CJ, Leslie KE, Walton JS, Johnson WH. Endometrial cytology and ultrasonography for the detection of subclinical endometritis in post-partum dairy cows. Theriogenol 2004; 62: 9-23
• 14 Kasimanickam R, Duffield TF, Foster RA, Gartley CJ, Leslie KE, Walton JS, Johnson WH. A comparison of the cytobrush and uterine lavage techniques to evaluate endometrial cytology in clinically normal postpartum dairy cows. Can Vet J 2005; 46: 255-259
• 15 Kaufmann TB, Drillich M, Tenhagen BA, Forderung D, Heuwieser W. Prevalence of bovine subclinical endometritis 4 h after insemination and its effects on first service conception rate. Theriogenol 2009; 71: 385-391
• 16 Kaufmann TB, Drillich M, Tenhagen BA, Heuwieser W. Correlations between periparturient serum concentrations of non-esterified fatty acids, beta-hydroxybutyric acid, bilirubin, and urea and the occurrence of clinical and subclinical postpartum bovine endometritis. BMC Vet Res 2010; 6: 47
• 17 Knutti B, Küpfer U, Busato A. Reproductive efficiency of cows with endometritis after treatment with intrauterine infusions or prostaglandin injections, or no treatment. J Vet Med 2000; 47: 609-615
• 18 LeBlanc SJ. Postpartum uterine disease and dairy herd reproductive performance: a review. Vet J 2008; 176: 102-114
• 19 LeBlanc SJ, Duffield TF, Leslie KE, Bateman KG, Keefe GP, Walton JS, Johnson WH. The effect of treatment of clinical endometritis on reproductive performance in dairy cows. J Dairy Sci 2002; 85: 2237-2249
• 20 Lefebvre RC, Stock AE. Therapeutic efficiency of antibiotics and prostaglandin F2α in postpartum dairy cows with clinical endometritis: an evidence-based evaluation. Vet Clin N Am: Food Anim Pract 2012; 28: 79-96
• 21 Lenz M, Drillich M, Heuwieser W. Evaluation of the diagnosis of subclinical endometritis in dairy cattle using ultrasound. Berlin Münchner Tierärztl Wochenschr 2007; 120: 237-244
• 22 Leutert C, von Krueger X, Plöntzke J, Heuwieser W. Evaluation of vaginoscopy for the diagnosis of clinical endometritis in dairy cows. J Dairy Sci 2012; 95: 206-212
• 23 Madoz LV, De La Sota RL, Suzuki K, Heuwieser W, Drillich M. Use of hysteroscopy for the diagnosis of postpartum clinical endometritis in dairy cows. Vet Rec 2010; 24: 142-143
• 24 McDougall S, Hussein H, Aberdein D, Buckle K, Roche J, Burke C, Mitchell M, Meier S. Relationships between cytology, bacteriology and vaginal discharge scores and reproductive performance in dairy cattle. Theriogenol 2011; 76: 229-240
• 25 Paisley LG, Mickelsen WD, Anderson PB. Mechanisms and therapy for retained fetal membranes and uterine infections of cows: a review. Theriogenol 1986; 25: 353-381
• 26 Pleticha S, Drillich M, Heuwieser W. Evaluation of the Metricheck device and the gloved hand for the diagnosis of clinical endometritis in dairy cows. J Dairy Sci 2009; 92: 5429-5435
• 27 Runciman DJ, Anderson GA, Malmo J, Davis GM. Effect of intrauterine treatment with cephapirin on the reproductive performance of seasonally calving dairy cows at risk of endometritis following periparturient disease. Austral Vet J 2008; 86: 250-258
• 28 Sheldon IM, Lewis GS, Leblanc SJ, Gilbert RO. Defining postpartum uterine disease in cattle. Theriogenol 2006; 65: 1516-1530
• 29 Westermann S, Drillich M, Kaufmann TB, Madoz LV, Heuwieser W. A clinical approach to determine false positive findings of clinical endometritis by vaginoscopy by the use of uterine bacteriology and cytology in dairy cows. Theriogenol 2010; 74: 1248-1255