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Planta Med 2012; 78(14): 1579-1593
DOI: 10.1055/s-0032-1315215
DOI: 10.1055/s-0032-1315215
Natural Product Chemistry
Original Papers
Structure Elucidation and Inhibitory Effects on NO Production of Clerodane Diterpenes from Ajuga decumbens
Weitere Informationen
Publikationsverlauf
received 10. Mai 2012
revised 25. Juni 2012
accepted 12. Juli 2012
Publikationsdatum:
07. August 2012 (online)
Abstract
Three new clerodane diterpenes (1–3), together with five known analogues (4–8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1–4 and 6–8 showed inhibitory effects.
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