New Monoterpenes, Diterpenes, and Lignans from Abies recurvata

Yong-Li Li; Ji-Gang Zhang; Ping Yu; Bei-Lei Ke; Ji Ye; Xian-Wen Yang; Hui-Zi Jin; Wei-Dong Zhang

doi:10.1055/s-0032-1315111

Planta Medica, Table of Contents

Planta Med 2012; 78(14): 1574-1578
DOI: 10.1055/s-0032-1315111

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

New Monoterpenes, Diterpenes, and Lignans from Abies recurvata

Yong-Li Li

¹School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

,

Ji-Gang Zhang

²School of Pharmacy, Second Military Medical University, Shanghai, China

,

Ping Yu

²School of Pharmacy, Second Military Medical University, Shanghai, China

,

Bei-Lei Ke

²School of Pharmacy, Second Military Medical University, Shanghai, China

,

Ji Ye

²School of Pharmacy, Second Military Medical University, Shanghai, China

,

Xian-Wen Yang

³Laboratory of Molecular and Cellular Oncology, Oncology Department, Luxembourg Public Research Center for Health (CRP-Santé), Luxembourg, Luxembourg

⁴Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China

,

Hui-Zi Jin

¹School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

,

Wei-Dong Zhang

¹School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

²School of Pharmacy, Second Military Medical University, Shanghai, China

› Author Affiliations

Abstract

From the aerial part of Abies recurvata, 62 miscellaneous chemical constituents were isolated including 6 new and 56 known ones. The new compounds comprised three monoterpenes, two diterpenes, and one lignan. Their chemical structures were characterized on the basis of various spectroscopic techniques. Dihydrodehydrodiconiferyl alcohol (35) showed the strongest inhibitory effects against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC₅₀ value of 66.4 µM.

Key words

Abies recurvate - Pinaceae - monoterpenes - diterpenes - lignin - nitric oxide - lipopolysaccharide

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References

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