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Planta Med 2012; 78(12): 1332-1336
DOI: 10.1055/s-0032-1315019
Biological and Pharmacological Activities
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ 1–42-induced Memory Impairment in Mice

Di Hu
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Changxia Li
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Na Han
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Lijing Miao
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Dong Wang
2   Department of Neurosurgery, First Hospital Affiliated to Jilin University, Changchun, China
,
Zhihui Liu
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Hua Wang
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Jun Yin
1   Department and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
› Author Affiliations
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Publication History

received 14 March 2012
revised 30 May 2012

accepted 11 June 2012

Publication Date:
06 July 2012 (online)

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Abstract

In the present study, we examined the effects of deoxyschisandrin (DS) from Schisandra chinensis on the amyloid-beta1–42 (Aβ 1–42)-induced memory impairment in mice and investigated the possible antioxidative mechanism. Mice were given an intracerebroventricular (i. c. v.) injection with the aggregated Aβ 1–42 and then treated with DS (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a positive control drug (0.65 mg/kg), by intragastric infusion for 14 days. Non-cognitive disturbances and cognitive performance were evaluated by the locomotor activity, Y-maze, and water maze tests. Antioxidative enzyme activities including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and levels of malondialdehyde (MDA), glutathione (GSH), and oxidized glutathione (GSSG) within the cerebral cortex and hippocampus of mice were measured to investigate the mechanism. Our results showed that DS significantly improved Aβ 1–42-induced short-term and spatial memory impairments in the Y-maze and water maze tests. Furthermore, in the cerebral cortex and hippocampus of mice, the reduced activities of SOD and GSH-px, the GSH level, and the GSH/GSSG ratio were increased, and increased levels of MDA and GSSG were reduced following treatment with DS, although the improvement of GSH and the reduction of GSSG levels were not marked. These results suggest that DS is a potential cognitive enhancer in Alzheimerʼs disease through its antioxidative action.

Key words

Schisandra chinensis - Magnoliaceae - deoxyschisandrin - amyloid-beta1–42 - Alzheimerʼs disease - antioxidative action

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