Papillary Glioneuronal Tumor: Unexplored Entity^[*]

Abstract

Papillary glioneuronal tumors represent a new and rare entity of an uncommon morphologic subtype of low-grade mixed neuronal-glial neoplasms with an unclear etiology. They are described as benign lesions with extraventricular localization. We report the second case of papillary glioneuronal tumor with recurrent nature after gross-total resection, and the third case of this tumor with intraventricular localization. While conventional magnetic resonance imaging of papillary glioneuronal tumors is well described in literature, there are no data based on advanced magnetic resonance techniques. The present article represents a review of clinicopathological and both conventional and advanced magnetic resonance imaging characteristics of papillary glioneuronal tumors, with focus on 2 cases with atypical course and localization.

Keywords

papillary glioneuronal tumor - recurrence - intraventricular localization - magnetic resonance imaging - diffusion - perfusion - magnetic resonance spectroscopy

^* This article was originally published online in Central European Neurosurgery on August 12, 2011 (DOI:10.1055/s-0031-1280836)

• References

• 1 Allende DS, Prayson RA. The expanding family of glioneuronal tumors. Adv Anat Pathol 2009; 16 (1) 33-39
• 2 Al-Okaili RN, Krejza J, Wang S , et al. Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. Radiographics 2006; 26: S173-S189
• 3 Atri S, Sharma MC, Sarkar C , et al. Papillary glioneuronal tumour: a report of a rare case and review of literature. Childs Nerv Syst 2007; 23: 349-353
• 4 Benesch M, Eder HG, Sovinz P , et al. Residual or recurrent cerebellar low-grade glioma in children after tumor resection: is re-treatment needed? A single center experience from 1983 to 2003. Pediatr Neurosurg 2006; 42: 159-164
• 5 Borges G, Bonilha L, Menezes AS , et al. Long term follow-up in a patient with papillary glioneuronal tumor. Arq Neuropsiquiatr 2004; 62 (3-B) 869-872
• 6 Bouvier-Labit C, Daniel L, Dufour H , et al. Papillary glioneuronal tumour: clinicopathological and biochemical study of one case with 7-year follow up. Acta Neuropathol 2000; 99: 321-326
• 7 Broholm H, Madsen FF, Wagner AA , et al. Papillary glioneural tumor. A new tumor entity. Clin Neuropathol 2002; 21: 1-4
• 8 Celli P, Caroli E, Giangaspero F , et al. Papillary glioneuronal tumor. J Neurooncol 2006; 80: 185-189
• 9 Chen L, Piao YS, Xu QZ , et al. Papillary glioneuronal tumor: a clinicopathological and immunohistochemical study of two cases. Neuropathology 2006; 26: 243-248
• 10 Dim DC, Lingamfelter DC, Taboada EM , et al. Papillary glioneuronal tumor: a case report and review of the literature. Hum Pathol 2006; 37: 914-918
• 11 Epelbaum S, Kujas M, Van Effenterre R , et al. Two cases of papillary glioneuronal tumours. Br J Neurosurg 2006; 20: 90-93
• 12 Gelpi E, Preusser M, Czech T , et al. Papillary glioneuronal tumor. Neuropathology 2007; 27: 468-473
• 13 Govindan A, Mahadevan A, Bhat DI , et al. Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation. J Neurooncol 2009; 95: 71-80
• 14 Hourani R, Brant LJ, Rizk T , et al. Can proton MR spectroscopic and perfusion imaging differentiate between neoplastic and nonneoplastic brain lesion in adults?. Am J Neuroradiol 2008; 29: 366-272
• 15 Husain N, Husain M. Endoscopic diagnosis of a pineal papillary glioneuronal tumor with extensive ventricular involvement: Case report with review of literature. Neurology India 2009; 57 (6) 792-795
• 16 Ishizawa T, Komori T, Shibahara J , et al. Papillary glioneuronal tumor with minigemistocytic components and increased proliferarive activity. Hum Pathol 2006; 37: 627-630
• 17 Javahery RJ, Davidson L, Fangusaro J , et al. Aggressive variant of a papillary glioneuronal tumor. J Neurosurg Pediatr 2009; 3: 46-52
• 18 Komori T, Scheithauer BW, Anthony DC , et al. Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol 1998; 22: 1171-1183
• 19 Lamszus K, Makrigeorgi-Butera M, Laas R , et al. September 2002: 24-year-old female with a 6-month history of seizures. Brain Pathol 2003; 13: 115-117
• 20 Mahajan H, Varikatt W, Dexter M , et al. Papillary glioneuronal tumor of the frontal lobe. J Clin Neurosci 2010; 17 (4) 534-536
• 21 Nakazato Y, Figarella-Branger D, Becker AJ , et al. Papillary glioneuronal tumour. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, , (eds). WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC; 2007: 113-114
• 22 Newton HB, Dalton J, Ray-Chaudhury A , et al. Aggressive papillary glioneuronal tumor: case report and literature review. Clin Neuropathol 2008; 27: 317-324
• 23 Prayson RA. Papillary glioneural tumor. Arch Pathol Lab Med 2000; 20: 558-563
• 24 Stosic-Opincal T, Peric V, Gavrilovic S , et al. Papillary glioneuronal tumor. AJR Am J Roentgenol 2005; 185: 265-267
• 25 Tanaka Y, Yokoo H, Komori T , et al. A distinct pattern of Olig2-positive cellular distribution in papillary glioneuronal tumors: a manifestation of the oligodendroglial phenotype?. Acta Neuropathol 2005; 110: 39-47
• 26 Tsukayama C, Arakawa Y. A papillary glioneuronal tumor arising in an elderly woman: a case report. Brain Tumor Pathol 2002; 19: 35-39
• 27 Vaquero J, Coca S. Atypical papillary glioneuronal tumor. J Neurooncol 2007; 83: 319-323
• 28 Williams SR, Beth BW, Parker JC , et al. Papillary glioneuronal tumor: a case report and review of the literature. Ann Clin Lab Sci 2008; 38 (3) 287-292
• 29 Xiao H, Ma L, Lou X , et al. Papillary glioneuronal tumor: radiological evidence of a newly established tumor entity. J Neuroimaging 2011; 21 (3) 297-302
• 30 Yamasaki F, Kurisu K, Satoh K , et al. Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 2005; 235 (3) 985-991
• 31 Pimentel J, Barroso C, Miguéns J , et al. Papillary glioneuronal tumor-prognostic value of the extension of surgical resection. Clin Neuropathol 2009; 28 (4) 287-294
• 32 Phi JH, Park SH, Chae JH , et al. Papillary glioneuronal tumor present in a patient with encephalocraniocutaneous lipomatosis: case report. Neurosurgery 2010; 67 (4) E1165-E1169
• 33 Rainov NG, Wagner T, Heidecke V. Rosette-forming glioneuronal tumor of the fourth ventricle. Cen Eur Neurosurg 2010; 71 (4) 219-221