Z Gastroenterol 2012; 50 - A47
DOI: 10.1055/s-0032-1312401

Evolution of the disease behavior in pediatric and adult onset CD in a population-based incident cohort from western Hungary

B Lovász 1, P Lakatos 1, Á Horváth 3, T Pandur 2, Z Erdélyi 2, G Mester 4, M Balogh 4, I Szipocs 5, C Molnár 6, E Komáromi 7, P Golovics 1, L Kiss 1, L Lakatos 2
  • 11st Department of Medicine, Semmelweis University, Budapest, Hungary
  • 2Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary
  • 3Department of Pediatrics, Csolnoky F. Province Hospital, Veszprem, Hungary
  • 4Department of Medicine, Grof Eszterhazy Hospital, Papa, Hungary
  • 5Department of Medicine, Municipal Hospital, Tapolca, Hungary
  • 6Department of Infectious Diseases, Magyar Imre Hospital, Ajka, Hungary
  • 7Deptartment of Gastroenterology Municipal Hospital, Varpalota, Hungary

Background and Aims: The disease behaviour is changing significantly during the disease course in patients with Crohn's disease. Limited data are available however, if the trends are similar or different in pediatric and adult onset CD populations. Therefore our aim was to analyze the time trends of disease behavior in the population-based Veszprem province database, which included incident patients diagnosed between January 1, 1977 and December 31, 2008 in adult and pediatric onset CD populations.

Methods: Data of 506 incident CD patients were analyzed (median age-at-diagnosis: 31.5 SD13.8years). Both in- and outpatient records were collected and comprehensively reviewed.

Results: 74 (14.6%) CD patients were diagnosed ≤18 years of age. There was no significant difference in the distribution of disease behaviour between pediatric (B1: 62%, B2: 15% and B3: 23%) and adult onset CD patients (B1: 56%, B2: 21% and B3: 23%) at diagnosis or during follow-up (p=NS). Similarly, time to change in disease behaviour from B1 to B2/B3 disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis. The probability of complicated disease behaviour was 27.5% and 51.7% in the pediatric and 34.3% and 56.4% in the adult onset patients after 5- and 10-years of follow-up (p=NS).

Conclusions: The long-term evolution of the disease behaviour in pediatric and adult onset CD patients was not different in this population-based incident cohort.